![]() Join us in congratulating Stephanie for passing her defence! Wishing you all the best as you write your future! view |
![]() Join us in congratulating Nicole for passing her defence! We're so proud of all the work you've knitted together in the past 6 years! view |
![]() Join us in congratulating Jamie for passing her defence! Jamie, we love you ❤️ (and sugars... and crosswords and pokemon...) view |
![]() We have developed a new bioorthogonal reaction usingTePhe, a tellurophene-based phenylalanine analogue. This reaction, called oxidation-controlled, strain-promoted tellurophene-alkyne cycloaddition (OSTAC), involves mild oxidation of tellurophene to create a reactive species that rapidly cyclizes with bicyclo[6.1.0]nonyne (BCN). OSTAC allows for selective labeling of proteins in complex mixtures and can be combined with other reactions like SPAAC and CuAAC, showing broad potential in... view |
![]() Pokemon reminded us to wear our personal protective equipment. Prioritize safety, unlock better chemistry! view |
![]() A round of applause for Master Amanda who completed her M.Sc. exit seminar on desulfurative cross-coupling of thioglycosides! Your hard work has set a high bar for excellence in our lab. Well done!*pictured is Amanda's pet snake Ruby 🐍 view |
![]() Our new paper presents how N-azidoacetylglucosamine (GlcNAz) can be incorporated into bacterial peptidoglycan for metabolic labeling in Escherichia coli. By the expression of NahK in E. coli, the cytosolic production of UDP-GlcNAz and preferential incorporation into peptidoglycan (PGN) over other sites like poly-β-1,6-N-acetylglucosamine (PNAG), lipopolysaccharide (LPS), or enterobacterial common antigen (ECA) was revealed, providing insights for future development of carbohydrate-based... view |
![]() See our recent publication (starred with Editor's Choice⭐) on designing and implementing the first mass cytometry ligands compatible with the HaloTag system. Employing "click"-amenable HaloTag warheads conjugated metal-chelating polymers, we demonstrated successful labelling of HEK293T cells. https://doi.org/10.1021/acs.bioconjchem.3c00434 view |
![]() Our newest publication offers a promising addition to the toolbox of bioorthogonal reactions in chemical biology! We present a cascade reaction between N-allylglyoxylamide and N-alkylhydroxylamine, catalyzed by 5-methoxyanthranilic acid, combining the reactivity of nitrones with the simplicity of aldehydes, demonstrating bioorthogonality in complex cell lysates and on the surface of HEK293 cells. https://doi.org/10.1021/acs.... view |
![]() As the holidays approach, the Nitz group is donning up with festivity ❄️ We present to you... The Coatmas Tree! Transforming perished lab coats into a festive decoration, we are embracing the holiday cheer with a dash of science and sustainability. view |