Announcements

Join us in congratulating Nicole for passing her defence! We're so proud of all the work you've knitted together in the past 6 years!

 Join us in congratulating Jamie for passing her defence! Jamie, we love you ❤️ (and sugars... and crosswords and pokemon...)

We have developed a new bioorthogonal reaction usingTePhe, a tellurophene-based phenylalanine analogue. This reaction, called oxidation-controlled, strain-promoted tellurophene-alkyne cycloaddition (OSTAC), involves mild oxidation of tellurophene to create a reactive species that rapidly cyclizes with bicyclo[6.1.0]nonyne (BCN). OSTAC allows for selective labeling of proteins in complex mixtures and can be combined with other reactions like SPAAC and CuAAC, showing broad potential in... view

Pokemon reminded us to wear our personal protective equipment. Prioritize safety, unlock better chemistry!

A round of applause for Master Amanda who completed her M.Sc. exit seminar on desulfurative cross-coupling of thioglycosides! Your hard work has set a high bar for excellence in our lab. Well done!*pictured is Amanda's pet snake Ruby 🐍

Our new paper presents how N-azidoacetylglucosamine (GlcNAz) can be incorporated into bacterial peptidoglycan for metabolic labeling in Escherichia coli. By the expression of NahK in E. coli, the cytosolic production of UDP-GlcNAz and preferential incorporation into peptidoglycan (PGN) over other sites like poly-β-1,6-N-acetylglucosamine (PNAG), lipopolysaccharide (LPS), or enterobacterial common antigen (ECA) was revealed, providing insights for future development of carbohydrate-based... view

See our recent publication (starred with Editor's Choice⭐) on designing and implementing the first mass cytometry ligands compatible with the HaloTag system. Employing "click"-amenable HaloTag warheads conjugated metal-chelating polymers, we demonstrated successful labelling of HEK293T cells. https://doi.org/10.1021/acs.bioconjchem.3c00434 

Our newest publication offers a promising addition to the toolbox of bioorthogonal reactions in chemical biology! We present a cascade reaction between N-allylglyoxylamide and N-alkylhydroxylamine, catalyzed by 5-methoxyanthranilic acid, combining the reactivity of nitrones with the simplicity of aldehydes, demonstrating bioorthogonality in complex cell lysates and on the surface of HEK293 cells. https://doi.org/10.1021/acs.... view