Research in Bio-organic Chemistry
Congratulations Amanda!
A round of applause for Master Amanda who completed her M.Sc. exit seminar on desulfurative cross-coupling of thioglycosides! Your hard work has set a high bar for excellence in our lab. Well done!*pictured is Amanda's pet snake Ruby 🐍 view |
Congratulations to Alex on publishing in ACS Chemical Biology!
Our new paper presents how N-azidoacetylglucosamine (GlcNAz) can be incorporated into bacterial peptidoglycan for metabolic labeling in Escherichia coli. By the expression of NahK in E. coli, the cytosolic production of UDP-GlcNAz and preferential incorporation into peptidoglycan (PGN) over other sites like poly-β-1,6-N-acetylglucosamine (PNAG), lipopolysaccharide (LPS), or enterobacterial common antigen (ECA) was revealed, providing insights for future development of carbohydrate-based... view |
Cheers to Nicole on publishing in ACS Bioconjugate Chemistry!
See our recent publication (starred with Editor's Choice⭐) on designing and implementing the first mass cytometry ligands compatible with the HaloTag system. Employing "click"-amenable HaloTag warheads conjugated metal-chelating polymers, we demonstrated successful labelling of HEK293T cells. https://doi.org/10.1021/acs.bioconjchem.3c00434 view |
Congratulations Daniel and Hunter for getting your work accepted to ACS Bioconjugate Chemistry!
Our newest publication offers a promising addition to the toolbox of bioorthogonal reactions in chemical biology! We present a cascade reaction between N-allylglyoxylamide and N-alkylhydroxylamine, catalyzed by 5-methoxyanthranilic acid, combining the reactivity of nitrones with the simplicity of aldehydes, demonstrating bioorthogonality in complex cell lysates and on the surface of HEK293 cells. https://doi.org/10.1021/acs.... view |
🌲O Coatmas Tree🌲
As the holidays approach, the Nitz group is donning up with festivity ❄️ We present to you... The Coatmas Tree! Transforming perished lab coats into a festive decoration, we are embracing the holiday cheer with a dash of science and sustainability. view |
Congratulations Miya!
We are proud to announce that Miya successfully completed her M.Sc. exit seminar! Miya has been with us since her fourth year of undergrad, exploring NahK-mediated metabolic oligosaccharide engineering with N-azidoacetylglucosamine derivatives in E. coli. We wish her the best of luck as she embarks on the next chapter of her academic journey, pursuing a PhD in Denmark! view |
Spooky Nails 😈
Spooky Tellurium nails and the cursed peptide haunt the Nitz lab!💅 by Stephanie view |
Congratulations Dr. Eddenden!
Join us in congratulating Alex for passing his defence! view |
Alex is giving his FOE Seminar on Sept 25th
Our very own Alex is defending in approximately two weeks! Here are the details:
Title: Probing for N-acetylglucosamine in the Glycans of Escherichia coli Date: September 25th, 2023 at 9 am EST Location: Davenport East Seminar Room, LM Building Remote Meeting ID: 864 2288 3168 (https://utoronto.zoom.us/j/86422883168) Passcode: 173090
Abstract: The glycobiology of bacteria is fundamental to understanding... view |
Best of luck, Helen!
Today was Helen's last day of working with us. Since joining the lab in 2021, she worked on the development of tellurium-based mitochondrial probes for mass cytometry. She gave her MSc exit seminar in April 2023, then stayed with us for a little longer as a research associate to wrap up her work. Thanks Helen, for always being helpful and supportive. We all (Prof Nitz, the members, and the Biotage) will miss you very much!!! view |