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Synthesis of C6-substituted UDP-GlcNAc derivatives.

TitleSynthesis of C6-substituted UDP-GlcNAc derivatives.
Publication TypeJournal Article
Year of Publication2020
AuthorsMorrison, ZA, Nitz, M
JournalCarbohydr Res
Volume495
Pagination108071
Date Published2020 Sep
ISSN1873-426X
Abstract

UDP-sugar analogs are useful for the study of glycosyltransferases and the production of unnatural glycans. The preparation of five UDP-GlcNAc derivatives is reported with 6-deoxy, 6-azido, 6-amino, 6-mercapto, or 6-fluoro substitutions. A concise chemoenzymatic synthesis was developed using the kinase NahK (B. longum JCM1217) and the uridyl transferase GlmU (E. coli K12).
DOI10.1016/j.carres.2020.108071
Alternate JournalCarbohydr Res
PubMed ID32634644