Macrocycles and peptides
We develop and apply new methods for making complex macrocycles. This effort involves discovery of new cyclization reactions and careful spectroscopic characterization of our molecules with the goal of understanding their conformation. Representative examples:
- Huh, S.; Saunders, G. J.; Yudin, A. K. “Single Atom Ring Contraction of Peptide Macrocycles Using Cornforth Rearrangement,” Angew. Chem. Int. Ed. 2022, 134, https://doi.org/10.1002/ange.202214729
- Saunders, G. J.; Yudin, A. K. “Property-Driven Development of Passively Permeable Macrocyclic Scaffolds Using Heterocycles,” Angew. Chem. Int. Ed. 2022, 134, e202206866
- Diaz, D. B.; Appavoo, S. D. Bogdanchikova, A. F.; Lebedev, Y.; McTiernan, T. J.; Gomes, G.; Yudin, A. K. “Illuminating the Dark Conformational Space of Macrocycles Using Dominant Rotors,” Nat. Chem. 2021, 13, 218-225