Title | Conformationally stable peptide macrocycles assembled using the Petasis borono-Mannich reaction. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Yamaguchi, A, Kaldas, SJ, Appavoo, SD, Diaz, DB, Yudin, AK |
Journal | Chem Commun (Camb) |
Date Published | 2019 Aug 16 |
ISSN | 1364-548X |
Abstract | Macrocyclization of linear peptide precursors using the Petasis borono-Mannich reaction affords a diverse range of macrocycles with an endocyclic amine. Analysis of the corresponding macrocyclic structures underscores that the hydrogen bond between an endocyclic amine and the adjacent amide NH is a powerful control element for conformationally homogenous peptide macrocycles. |
DOI | 10.1039/c9cc05934b |
Alternate Journal | Chem. Commun. (Camb.) |
PubMed ID | 31417998 |