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Borylated reagents for multicomponent reactions.

TitleBorylated reagents for multicomponent reactions.
Publication TypeJournal Article
Year of Publication2018
AuthorsTan, J, Yudin, AK
JournalDrug Discov Today Technol
Volume29
Pagination51-60
Date Published2018 Nov
ISSN1740-6749
KeywordsBoron Compounds, Bortezomib, Chemistry Techniques, Synthetic, Chemistry, Pharmaceutical, Cyanides, Molecular Structure, Phospholipases, Proteasome Inhibitors
Abstract

Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs). In particular, the development of borylated building blocks has provided facile access to difficult-to-access heteroatom-rich BCMs. In this review, we will discuss the methods used to prepare boron-containing molecules of biological relevance from multicomponent reactions with borylated building blocks.

DOI10.1016/j.ddtec.2018.08.002
Alternate JournalDrug Discov Today Technol
PubMed ID30471674