%0 Journal Article %J Drug Discov Today Technol %D 2018 %T Borylated reagents for multicomponent reactions. %A Tan, Joanne %A Yudin, Andrei K %K Boron Compounds %K Bortezomib %K Chemistry Techniques, Synthetic %K Chemistry, Pharmaceutical %K Cyanides %K Molecular Structure %K Phospholipases %K Proteasome Inhibitors %X

Over the past two decades, there has been an increasing interest in the therapeutic potential of organoboron reagents due to the discovery of bortezomib (Velcade). This has motivated synthetic chemists to develop novel routes for the preparation of heteroatom-rich boron-containing molecules (BCMs). In particular, the development of borylated building blocks has provided facile access to difficult-to-access heteroatom-rich BCMs. In this review, we will discuss the methods used to prepare boron-containing molecules of biological relevance from multicomponent reactions with borylated building blocks.

%B Drug Discov Today Technol %V 29 %P 51-60 %8 2018 Nov %R 10.1016/j.ddtec.2018.08.002