@article {92,
	title = {Hydroxylated 2-Ethylhexyl tetrabromobenzoate isomers in house dust and their agonistic potencies with several nuclear receptors.},
	journal = {Environ Pollut},
	volume = {227},
	year = {2017},
	month = {2017 Aug},
	pages = {578-586},
	abstract = {<p>In the current study, by combining ultra-high resolution (UHR) MS spectra, MS spectra, and derivatization, three hydroxylated isomers of 2-ethylhexyl tetrabromobenzoate (OH-TBB) were identified in Firemaster 550 and BZ-54 technical products. Also, a new LC-UHRMS method, using atmospheric pressure chemical ionization (APCI), was developed for simultaneous analysis of OH-TBB, TBB, hydroxylated bis(2-ethylhexyl)-tetrabromophthalate (OH-TBPH) and TBPH in 23 samples of dust collected from houses in Saskatoon, SK, Canada. OH-TBBs were detected in 91\% of samples, with a geometric mean concentration of 0.21\&nbsp;ng/g, which was slightly less than those of OH-TBPH (0.35\&nbsp;ng/g). TBB was detected in 100\% of samples of dust with a geometric mean concentration of 992\&nbsp;ng/g. Significant (p\&nbsp;\&lt;\&nbsp;0.001) log-linear relationships between concentrations of OH-TBBs, TBB, or OH-TBPHs and TBPH in dust support the hypothesis of a common source of these compounds. OH-TBBs were found to be strong agonists of peroxisome proliferator-activated receptor gamma (PPARγ) and weaker agonists of the estrogen receptor (ER), but no agonistic potencies was observed with the androgen receptor (AR). Occurrence of OH-TBBs in technical products and house dust, together with their relatively strong PPARγ potencies, indicated their potential risk to health of humans.</p>},
	keywords = {Air Pollution, Indoor, Bromobenzoates, Canada, Dust, Environmental Monitoring, Flame Retardants, Halogenated Diphenyl Ethers, Humans},
	issn = {1873-6424},
	doi = {10.1016/j.envpol.2017.04.094},
	author = {Peng, Hui and Sun, Jianxian and Saunders, David M V and Codling, Garry and Wiseman, Steve and Jones, Paul D and Giesy, John P}
}
@article {103,
	title = {Untargeted Screening and Distribution of Organo-Bromine Compounds in Sediments of Lake Michigan.},
	journal = {Environ Sci Technol},
	volume = {50},
	year = {2016},
	month = {2016 Jan 05},
	pages = {321-30},
	abstract = {<p>Previously unreported natural and synthetic organo-bromine compounds (NSOBCs) have been found to contribute more than 99\% of total organic bromine (TOB) in environmental matrices. We recently developed a novel untargeted method (data-independent precursor isolation and characteristic fragment, DIPIC-Frag) and identified \~{}2000 NSOBCs in two sediments from Lake Michigan. In this study, this method was used to investigate the distributions of these NSOBCs in 23 surficial samples and 24 segments of a sediment core from Lake Michigan. NSOBCs were detected in all 23 surficial samples and exhibited 10- to 100-fold variations in peak abundance among locations. The pattern of distributions of NSOBCs was correlated with depth of the water column (r(2) = 0.61, p \&lt; 0.001). Hierarchical cluster analysis showed that sediments in close proximity exhibited similar profiles of NSOBCs. Distributions of NSOBCs in 24 segments of a sediment core dated from 1766 to 2008 were investigated, and samples from similar depths exhibited similar profiles of NSOBCs. NSOBCs were grouped into four clusters (soft-cluster analysis) with different temporal trends of abundances. 515 and 768 of the NSOBCs were grouped into cluster 1 and cluster 3 with increasing temporal trends, especially since 1950, indicating that abundances of these compounds might have been affected by human activities.</p>},
	keywords = {Bromine Compounds, Environmental Monitoring, Geologic Sediments, Halogenated Diphenyl Ethers, Hydrocarbons, Brominated, Lakes, Michigan, Water Pollutants, Chemical},
	issn = {1520-5851},
	doi = {10.1021/acs.est.5b04709},
	author = {Peng, Hui and Chen, Chunli and Cantin, Jenna and Saunders, David M V and Sun, Jianxian and Tang, Song and Codling, Garry and Hecker, Markus and Wiseman, Steve and Jones, Paul D and Li, An and Rockne, Karl J and Sturchio, Neil C and Giesy, John P}
}
