@article {114,
	title = {Derivatization method for sensitive determination of fluorotelomer alcohols in sediment by liquid chromatography-electrospray tandem mass spectrometry.},
	journal = {J Chromatogr A},
	volume = {1288},
	year = {2013},
	month = {2013 May 03},
	pages = {48-53},
	abstract = {<p>Fluorotelomer alcohols (FTOHs) are the main precursors of environmentally ubiquitous perfluorinated acids, and determination of FTOHs at low concentrations presents significant challenges. In this study, a new liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method in conjunction with low-energy collision dissociation tandem mass spectrometry (CID-MS/MS) was developed by employing an optimized derivatization reaction with dansyl chloride (DNS) in acetonitrile under catalysis of 4-(dimethylamino)-pyridine (DMAP). The instrument detection limits (IDLs) of the newly developed method were 0.014, 0.015, 0.014, 0.0075 and 0.0093μg/L for 4:2 FTOH, 6:2 FTOH, 8:2 FTOH, 10:1 FTOH and 10:2 FTOH respectively, which were 7.5-241 times lower than those without derivatizaiton and 57-357 times lower than previous GC/MS method. The method was successfully applied to analyze FTOHs in sediments combined with WAX and silica cartridges cleanup. The overall method recoveries were from 67{\textpm}6.0\% to 83{\textpm}9.4\% with matrix effects of \&lt;15\%. The limits of quantification for all FTOHs were 0.017-0.060ng/gdry weight (dw). The method was applied to analyze six marine sediment samples from Liaodong Bay, China. All FTOHs except for 10:1 FTOH were detected, and the total concentrations of FTOHs were 0.19-0.52ng/gdw. The developed method provides a new method to sensitively determine FTOHs in environmental matrices.</p>},
	keywords = {Alcohols, China, Chromatography, High Pressure Liquid, Environmental Pollutants, Fluorocarbons, Geologic Sediments, Reproducibility of Results, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization, Tandem Mass Spectrometry},
	issn = {1873-3778},
	doi = {10.1016/j.chroma.2013.02.085},
	author = {Peng, Hui and Hu, Kejun and Zhao, Fanrong and Hu, Jianying}
}
