@article {293,
	title = {A Rapid Testing Kit for 6PPD Screening in Rubber Products.},
	journal = {Anal Chem},
	year = {2025},
	month = {2025 Apr 26},
	abstract = {<p>-(1,3-dimethylbutyl)--phenyl--phenylenediamine (6PPD) has received increasing attention due to its ubiquitous environmental occurrence and extreme aquatic toxicity of its oxidation product 6PPD-quinone. Given 6PPD{\textquoteright}s application as an antioxidant in a wide array of rubber products, cost-effective detection of 6PPD is important for product and waste management. We herein developed a rapid testing kit for the detection (\&lt;10 min) of 6PPD in rubber products with low costs (\&lt;$1/sample), which was inspired by the observation of a red-colored product after 6PPD exposure to oxidants. The selectivity of this reaction was evaluated by 14 structurally diverse phenols and anilines. Interestingly, the protonated -1,3-dimethyl butyl--phenyl quinone diimine (6QDI+H), rather than its neutral or radical counterparts, appeared to be the red-colored product with λ = 490 nm. We further developed a "green" and user-friendly 6PPD rapid testing kit, which was further applied to a wide array of 50 rubber products. 6PPD was detected in 22 out of 50 samples, with a strong agreement ( = 0.896) observed between the results of the rapid testing kit and LC-MS. In summary, this study introduces a 6PPD rapid testing kit for users without requiring expertise in chemistry.</p>},
	issn = {1520-6882},
	doi = {10.1021/acs.analchem.5c00079},
	author = {Li, Zhuoyuan and Xie, Linna and Nair, Pranav and Yeung, Kirsten and Meek, Oliver and Tao, Juan and Hiki, Kyoshiro and Hao, Chunyan and Peng, Hui}
}
