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Publications

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Author Title Type [ Year(Asc)]
Filters: Author is Little, Dustin J  [Clear All Filters]
2022
Pfoh, R.; Subramanian, A. S.; Huang, J.; Little, D. J.; Forman, A.; DiFrancesco, B. R.; Balouchestani-Asli, N.; Kitova, E. N.; Klassen, J. S.; Pomès, R.; Nitz, M.; P Howell, L. The Tpr Domain Of Pgaa Is A Multifunctional Scaffold That Binds Pnag And Modulates Pgab-Dependent Polymer Processing. PLoS Pathog 2022, 18 (8), e1010750.
2018
Little, D. J.; Pfoh, R.; Le Mauff, F.; Bamford, N. C.; Notte, C.; Baker, P.; Guragain, M.; Robinson, H.; Pier, G. B.; Nitz, M.; Deora, R.; Sheppard, D. C.; P Howell, L. Pgab Orthologues Contain A Glycoside Hydrolase Domain That Cleaves Deacetylated Poly-Β(1,6)-N-Acetylglucosamine And Can Disrupt Bacterial Biofilms. PLoS Pathog 2018, 14 (4), e1006998.
2015
Ariyakumaran, R.; Pokrovskaya, V.; Little, D. J.; P Howell, L.; Nitz, M. Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates As Inhibitors Of Ce4 De-N-Acetylases. Chembiochem 2015, 16 (9), 1350-6.
Little, D. J.; Milek, S.; Bamford, N. C.; Ganguly, T.; DiFrancesco, B. R.; Nitz, M.; Deora, R.; P Howell, L. The Protein Bpsb Is A Poly-Β-1,6-N-Acetyl-D-Glucosamine Deacetylase Required For Biofilm Formation In Bordetella Bronchiseptica. J Biol Chem 2015, 290 (37), 22827-40.
2014
Little, D. J.; Li, G.; Ing, C.; DiFrancesco, B. R.; Bamford, N. C.; Robinson, H.; Nitz, M.; Pomès, R.; P Howell, L. Modification And Periplasmic Translocation Of The Biofilm Exopolysaccharide Poly-Β-1,6-N-Acetyl-D-Glucosamine. Proc Natl Acad Sci U S A 2014, 111 (30), 11013-8.
Little, D. J.; Bamford, N. C.; Pokrovskaya, V.; Robinson, H.; Nitz, M.; P Howell, L. Structural Basis For The De-N-Acetylation Of Poly-Β-1,6-N-Acetyl-D-Glucosamine In Gram-Positive Bacteria. J Biol Chem 2014, 289 (52), 35907-17.
2013
Pokrovskaya, V.; Poloczek, J.; Little, D. J.; Griffiths, H.; P Howell, L.; Nitz, M. Functional Characterization Of Staphylococcus Epidermidis Icab, A De-N-Acetylase Important For Biofilm Formation. Biochemistry 2013, 52 (32), 5463-71.
2012
Little, D. J.; Whitney, J. C.; Robinson, H.; Yip, P.; Nitz, M.; P Howell, L. Combining In Situ Proteolysis And Mass Spectrometry To Crystallize Escherichia Coli Pgab. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012, 68 (Pt 7), 842-5.
Little, D. J.; Poloczek, J.; Whitney, J. C.; Robinson, H.; Nitz, M.; P Howell, L. The Structure- And Metal-Dependent Activity Of Escherichia Coli Pgab Provides Insight Into The Partial De-N-Acetylation Of Poly-Β-1,6-N-Acetyl-D-Glucosamine. J Biol Chem 2012, 287 (37), 31126-37.
Chibba, A.; Poloczek, J.; Little, D. J.; P Howell, L.; Nitz, M. Synthesis And Evaluation Of Inhibitors Of E. Coli Pgab, A Polysaccharide De-N-Acetylase Involved In Biofilm Formation. Org Biomol Chem 2012, 10 (35), 7103-7.