
@article {140,
	title = {Intrinsic Turn-On Response of Thioflavin T in Complexes.},
	journal = {Chemistry},
	volume = {26},
	year = {2020},
	month = {2020 Mar 18},
	pages = {3479-3483},
	abstract = {<p>The fluorescence enhancement ("turn-on") response of the amyloid-sensing dye thioflavin T (ThT) is examined in vacuo, where solvent interactions are absent. Upon the complexation of ThT with a derivatized β-cyclodextrin, heptakis-[6-deoxy-6-(3-sulfanylpropanoic acid)]-β-cyclodextrin, turn-on responses in both the gas phase and solution phase were observed. In contrast, turn-on response was not detected when ThT was bound to gaseous cucurbit[7]uril or human telomeric DNA 22AG, whereas clear turn-on response occurs in solution. The observed difference in turn-on response in the gas phase emphasizes the key interplay between chromophore, host and solvent and demonstrates the utility of gas-phase spectroscopy to tease out the balance among intermolecular forces driving the behavior of important chromophores in solution.</p>},
	issn = {1521-3765},
	doi = {10.1002/chem.201905100},
	author = {Kung, Jocky C K and Vurgun, Nesrin and Chen, JoAnn C and Nitz, Mark and Jockusch, Rebecca A}
}
