Skip to content Skip to navigation

Synergistic Organoboron/Palladium Catalysis for Regioselective N-Allylation of 2-Pyridones, 4-Pyridones, and Related Ambident Heterocycles

TitleSynergistic Organoboron/Palladium Catalysis for Regioselective N-Allylation of 2-Pyridones, 4-Pyridones, and Related Ambident Heterocycles
Publication TypeJournal Article
Year of Publication2023
AuthorsYatzoglou, G, Zambri, MT, Desai, SP, Taylor, MS
JournalSynlett
IssueEFirst
Date Published2023/11/15
ISBN Number0936-52141437-2096
KeywordsAllylation, Boronic acids, heterocycles, palladium, regioselectivity
Abstract

The use of a boronic acid co-catalyst along with a palladium complex enables efficient dehydrative couplings of allylic alcohols and tautomerizable heterocycles. The protocol has been applied to achieve N-allylations of 2-pyridones, 4-pyridones, 4-pyrimidinones, and their benzo-fused derivatives.
URLhttp://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-1763618
Short TitleSynlett